4340 Duncan – Cortex Innovation Community

The adaptive reuse project transformed the 1930 Crescent
Building, a long-vacant structure listed on the National
Register of Historic Places, into a multitenant lab and office
facility for St. Louis’ growing bioscience startup community.
The building, once a printing plant for the St. Louis Post-
Dispatch, now features modern lab and office spaces
within its historic walls. The team preserved the building’s
industrial character while introducing a new space program,
including glass-walled office suites, labs, support spaces,
and meeting rooms within a multistory atrium that once
housed printing presses.
DG2 Design designed the new entrance with a generous
ramp and native landscaping, connected the streetscape
into the Cortex Community, and added a walkout terrace and
green roof atop a previous 1950s addition to the building.